Do Cognitive Subtypes Exist in People at Clinical High Risk for Psychosis? Results From the EU-GEI Study

G Gifford; A Avila; MJ Kempton; P Fusar-Poli; RA Mccutcheon; F Coutts; S Tognin; L Valmaggia; L De Haan; M Van Der Gaag; B Nelson; C Pantelis; A Riecher-Rössler; R Bressan; N Barrantes-Vidal; MO Krebs; B Glenthøj; S Ruhrmann; G Sachs; BPF Rutten; J Van Os; P Mcguire; M Calem; G Modinos; E Velthorst; TC Kraan; DSV Dam; N Burger; P Mcgorry; GP Amminger; A Politis; J Goodall; S Borgwardt; E Studerus16; A Gadelha; E Brietzke; G Asevedo; E Asevedo; A Zugman; T Domínguez-Martínez; P Cristóbal-Narváez; TR Kwapil; M Monsonet; L Hinojosa; M Kazes; C Daban; J Bourgin; O Gay; C Mam-Lam-fook; D Nordholm; L Randers; K Krakauer; L Glenthøj; M Nordentoft; D Gebhard; J Arnhold; J Klosterkötter; I Lasser; B Winklbaur; PA Delespaul

Journal article

Do Cognitive Subtypes Exist in People at Clinical High Risk for Psychosis? Results From the EU-GEI Study

G Gifford, A Avila, MJ Kempton, P Fusar-Poli, RA Mccutcheon, F Coutts, S Tognin, L Valmaggia, L De Haan, M Van Der Gaag, B Nelson, C Pantelis, A Riecher-Rössler, R Bressan, N Barrantes-Vidal, MO Krebs, B Glenthøj, S Ruhrmann, G Sachs, BPF Rutten Show all

Schizophrenia Bulletin | OXFORD UNIV PRESS | Published : 2025

DOI: 10.1093/schbul/sbae133

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Abstract

Background and Hypothesis Cognition has been associated with socio-occupational functioning in individuals at Clinical High Risk for Psychosis (CHR-P). The present study hypothesized that clustering CHR-P participants based on cognitive data could reveal clinically meaningful subtypes. Study Design A cohort of 291 CHR-P subjects was recruited through the multicentre EU-GEI high-risk study. We explored whether an underlying cluster structure was present in the cognition data. Clustering of cognition data was performed using k-means clustering and density-based spatial clustering of applications with noise. Cognitive subtypes were validated by comparing differences in functioning, psychosis sy..

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University of Melbourne Researchers

Lucia Valmaggia Author

Barnaby Nelson Author

Christos Pantelis Author

Patrick McGorry Author

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Funding Acknowledgements

The EU-GEI project was supported by the European Community's Seventh Framework Program (HEALTH-F2-2009-241909; Project EU-GEI). AA was supported by Fundac & atilde;o para a Ciencia e a Tecnologia, scholarship ID SFRH/BD/115916/2016. RAM's work is funded by a Wellcome Trust Clinical Research Career Development (224625/Z/21/Z). Additional support was provided by a Medical Research Council Fellowship (MR/J008915/1 to MK). CP was supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (1105825), NHMRC L3 Investigator Grant (1196508). BN was supported by an NHMRC Senior Research Fellowship (1137687) and a University of Melbourne Dame Kate Campbell Fellowship. The Melbourne site was supported by NHMRC-EU Grant (567215). NBV was supported by Ministerio de Ciencia, Innovacion e Universidades (PSI2017-87512-C2-1-R).